The prospect of using cell-based interventions to treat neurological conditions raises several important ethical and policy questions. In this target article, we focus on issues related to the unique constellation of traits that characterize CBIs targeted at the central nervous system. In particular, there is at least a theoretical prospect that these cells will alter the recipients' cognition, mood, and behavior—brain functions that are central to our concept of the self. The potential for such changes, although perhaps remote, is cause (...) for concern and careful ethical analysis. Both to enable better informed consent in the future and as an end in itself, we argue that early human trials of CBIs for neurological conditions must monitor subjects for changes in cognition, mood, and behavior; further, we recommend concrete steps for that monitoring. Such steps will help better characterize the potential risks and benefits of CBIs as they are tested and potentially used for treatment. (shrink)

There is a lack of consensus on whether the derivation and use of human embryonic stem cells (hESCs) from embryos remaining after infertility treatment morally require the informed consent of third-party gamete donors who contributed to the creation of the embryos. The principal guidelines for oversight and funding of hESC research in the United States make minimal or no demands for consent from gamete donors. In this article, I consider the arguments supporting and opposing gamete donor consent for hESC research (...) and embryo research more broadly. I argue that it is not morally permissible to use leftover embryos in research without the informed consent of gamete donors, and that we should place restrictions on the use of existing hESC lines that may have been derived without informed consent. While the standard argument for this position relies on an appeal to gamete donors’ interest in controlling what happens with their genetic material, I identify shortcomings with the standard approach and seek instead to locate the deeper moral foundations for gamete donor consent in rights to bodily integrity. (shrink)

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

We present counterexamples to the widespread assumption that Moorean sentences cannot be rationally asserted. We then explain why Moorean assertions of the sort we discuss do not incur the irrationality charge. Our argument involves an appeal to the dual-process theory of the mind and a contrast between the conditions for ascribing beliefs to oneself and the conditions for making assertions about independently existing states of affairs. We conclude by contrasting beliefs of the sort we discuss with the structurally similar but (...) rationally impermissible beliefs of certain psychiatric patients. (shrink)

The essay "Augustine's View of Reality" was originally delivered by Dr. Bourke at St. Louis University as the 1963 Saint Augustine Lecture. To it, he has added here seventy-five pages of bilingual texts from Augustine, in which various metaphysical matters are treated, and four "appendices" in which Dr. Bourke carries out in greater detail the ideas advanced in his lecture. Dr. Bourke intends to explore the specifically metaphysical aspects of Augustine's writings, and in effect compares Augustine's Christian Platonism with Thomistic (...) metaphysics. He discusses Augustine's conception of the relation between being and essence, and his conception of the being of God. In the appendices, Dr. Bourke considers Augustine's approach to the subjects of Participation, Causality, Analogy, and the idipsum of God. While Dr. Bourke acknowledges from the start the extraction of a metaphysical system from the specifically theological writings of St. Augustine cannot do the entirety of those writings justice, it remains doubtful that this comparison of St. Augustine's thought with Thomism on the ground of the latter, is at all a fruitful way of understanding the real religious insights of the bishop of Hippo.—A. W. W. (shrink)

Spend a year dwelling on the awesomeness of God with A. W. Tozer. He will expand your faith in a God so great that words fall short to describe Him. He will nourish you with truth. Encounter Tozer's heart and wisdom like never before in this newly revised edition.

(1978). Democratic Values and the Managerial Prerogative: a case study of headteachers and democratised school boards. Educational Studies: Vol. 4, No. 1, pp. 29-44.

This article is about the history of logic in Australia. Douglas Gasking (1911?1994) undertook to translate the logical terminology of John Anderson (1893?1962) into that of Ludwig Wittgenstein's (1921) Tractatus. At the time Gilbert Ryle (1900?1976), and more recently David Armstrong, recommended the result to students; but it is reasonable to have misgivings about Gasking as a guide to either Anderson or Wittgenstein. The historical interest of the debate Gasking initiated is that it yielded surprisingly little information about Anderson's traditional (...) (syllogistic or Aristotelian) logic and its relation to classical (first-order predicate or Russellian) logic, the ostensible topic; but the materials now exist to interpret Anderson's logic in classical logic, possibly as an algebra of classes. This would be of little interest to contemporary logicians, but it might shed some light on Anderson's philosophy. (shrink)

This essay constitutes an attempt to probe the very idea of a saying/showing distinction of the kind that Wittgenstein advances in the Tractatus—to say what such a distinction consists in, to say what philosophical work it has to do, and to say how we might be justified in drawing such a distinction. Towards the end of the essay the discussion is related to Wittgenstein’s later work. It is argued that we can profitably see this work in such a way that (...) a saying/showing distinction arises there too. In particular, in the final sub-section of the essay, it is suggested that we can see in Wittgenstein’s later work an inducement to say what we are shown. (shrink)

The Human A Priori is a collection of essays by A. W. Moore, one of them previously unpublished and the rest all revised. These essays are all concerned, more or less directly, with something ineliminably anthropocentric in our systematic pursuit of a priori sense-making. Part I deals with the nature, scope, and limits of a priori sense-making in general. Parts II, III, and IV deal with what are often thought to be the three great exemplars of the systematic pursuit of (...) such sense-making: philosophy in the case of Part II, ethics in the case of Part III, and mathematics in the case of Part IV. Much of the attention throughout is devoted to the work of other philosophers: Kant and Wittgenstein feature prominently, and five of the essays take the form of reviews or critical notices of recent work in philosophy. But the interest in never purely exegetical. One of the lessons that emerges from the essays, either in opposition to the views of these other philosophers or by invocation of their views, is that we humans achieve nothing of real significance in philosophy, ethics, or mathematics except from a human point of view, and hence that all three of these pursuits can be said to betoken what may reasonably be called 'the human a priori'. (shrink)

A. W. Price; VII*—Varieties of Objectivity and Values, Proceedings of the Aristotelian Society, Volume 83, Issue 1, 1 June 1983, Pages 103–120, https://doi.org/.

The National Anti-Vivisection Hospital opened to patients in 1903, the only district hospital in London not financed by state-controlled funds, which refused it support because of its principles. For three decades the hospital treated the local poor and conscientious objectors to vivisection, who were assured that staff pledged not to experiment on animals or patients. After an overambitious building program, the hospital ran into financial difficulties, and the King’s Fund refused to help unless all references to antivivisection were removed from (...) its statutes. Thus it reopened as Battersea General in 1935, continuing to serve the borough until 1972. (shrink)

This is a commentary on an article from "dialogue", march 1972: "first philosophy: metaphysics or epistemology?" by kenneth dorter. epistemologies from the time of descartes which have largely replaced ontology emphasize the human conditions for knowing, and where an ontology is lacking supply a knowledge by description with no objective world to describe. the humanism which refuses to go beyond mankind to learn about man elects to follow a path to extinction, and insofar as we hold to an egocentric viewpoint (...) in "first philosophy", a truly objective science of ontology has taken flight. (shrink)